Chiyedzo chekiriniki chepasi rose chechitatu chakasimbisa kushanda kwea Mushonga mutsva wemuromo wekufuta, orforglipron, muvanhu vakuru vakafutisa vasina chirwere cheshuga. Iyo data yakaburitswa muThe New England Journal of Medicine uye yakaunzwa pamusangano wepagore we European Association for the Study of Diabetes (EASD), yakaitirwa muVienna, nekubatanidzwa kunoshamisa kubva kuVall d'Hebron University Hospital.
Kuferefeta kwakaenderera mberi Mavhiki e72 kune 3.100 vanhu vanobva kunyika pfumbamwe uye akaongorora akati wandei mazuva ese madosi mumakapisi, anogara achiperekedzwa nekudya uye kurovedza muviri kurudziro. Zvichienzaniswa nesarudzo dzazvino, nzira yemuromo inorerutsa kurapwa uye inogona kukurudzira kutevedza kwenguva refu.
Chii chinonzi orforglipron uye nei ichikosha?
Orforglipron is a GLP-1 receptor agonist, chinangwa chikuru mu kudzora kwechido uye metabolism muuropi nemudumbu. Kusiyana nemishonga yakawanda mukirasi yayo, haisi peptide molecule, iyo inobvumira zvibate nemuromo pasina kuderedzwa mudumbu.
Izvi zvinoreva kuti hazvidi mamiriro akasimba emamwe marapirwo emuromo eiyo axis imwechete (somuenzaniso, kuvatora padumbu risina chinhu uye kumirira kwechinguva vasati vadya). Mukuita, its nyaradzo yekushandiswa inogona kuwedzera kuwanikwa uye kuita kuti zvive nyore kune varwere vakawanda kuchengetedza regimen.
Magadzirirwo akaitwa Phase 3 muyedzo
Vakuru vane BMI ≥30 kg/m² kana pakati pe27 ne30 kg/m² ne matambudziko ane chekuita nekufuta, zvakadai sehypertension, chirwere chemwoyo, kana kufema kwehope. Nhamba yekudzidza yakasiya vanhu vane chirwere cheshuga, izvo zvinobvumira ongorora maitiro pakurema pasina kurerekera kweglycemia.
Zvidzidzo zvakapihwa zvisina tsarukano Kurapa kunonyaradza pfungwa kana orforglipron mumhando dzakasiyana (6 mg, 12 mg kana 36 mg), inogara iri mukati capsule yezuva nezuva, pamwe nhungamiro yemararamiro ane hutanoIyi dhizaini yakatibvumidza kuti tiongorore kana mhedzisiro yacho yaienderana nedosi uye kuyera maitiro pane akawanda cardiometabolic paramita.
Main efficacy results
Pachiyero chepamusoro, kuyedzwa kwakanyora a avhareji kuderera kwe11,2% muhuremu hwemuviriVanopfuura hafu yevatori vechikamu vakawana kurasikirwa kwakaenzana kana kupfuura 10%, uye vanenge 18% yakapfuura 20%, nhamba dzinoenderana nekliniki nekuda kwehukama hwavo nehutano hwehutano.
Mukuwedzera kune uremu, kuvandudzwa kwakaonekwa mukati blood pressure, waist circumference uye lipid profile (triglycerides uye cholesterol), ese iwo mamark akabatanidzwa njodzi yemwoyo. Kuongororwa kwemuviri kunoratidza izvozvo Inenge 75% yehuremu yakarasika yaive mafuta uye chikamu chakati wandei chaienderana nemafuta e-visceral, anonyanya kuenderana nematambudziko emetabolic.
Kuchengeteka uye kushivirira
Migumisiro yakaipa yakataurwa ndiyo yakawanda kugaya (semuenzaniso, kuda kurutsa kana kusagadzikana kwegastric), kazhinji kupfava kana pakati uye kuzvidzora, ne yakafanana profile kune mamwe marapirwo ekufutisa.
Sezvo kufutisa kuri a chirwere chisingaperi, vanamazvikokota vanoomerera pakusashandisa mishonga iyi pano neapo kana kuti nokuda kwezvinangwa chete. Zvakakosha kuva nea chiratidzo chekurapa chakakwana, inofambira mberi titration uye kutevera, pamwe chete nekuchinja mararamiro uye, kana zvakakodzera, rubatsiro rwepfungwa.
Zvakanakira nzira yemuromo uye kuenderana kwayo nekurapa kwazvino
Kupesana neGLP-1 analogues jekiseni yatozivikanwa, senge oral semaglutide, iyo inoda yakasimba manejimendi mamiriro, orforglipron inopa a capsule sarudzo pasina zvirambidzo zvakadaroIchi chiitiko chinogona kuita kuti zvive nyore kune vanhu vanotora mishonga yakawanda uye kune avo, nekuda kwekuda kana logistics, vanoona zvichinetsa kuchengetedza majekiseni.
Mukutongwa, mushonga wacho wakaongororwa mukati kufutisa pasina chirwere cheshuga, iyo inoita kuti ive imwe nzira yekudzora uremu muboka iri. Kana mvumo yayo ikasimbiswa, yaizowedzera iyo catalog yesarudzo dze gadzirisa marapirwo acho zvinoenderana neprofile uye zvinodiwa nemurwere wega wega.
Chii chingauya manje
Vatsvakurudzi vanofanotaura kutanga kwe regulatory process mumwedzi iri kuuya. Kana ikawana mvumo yemasangano, inogona kumiririra nhanho inoshanda yekufambira mberi mukubatanidza kubudirira uye nzira yakapfava yekutonga, ichiwedzera kune azvino maitiro ekudzikisa cardiometabolic njodzi.
Nezvakawanda kupfuura 2.500 mamiriyoni evanhu kukanganiswa nehuremu hwakawandisa munyika, iva nemhando dzekurapa - dzinowedzerwa kudya kunovaka muviri, basa remuviri uye kliniki yekutevera- zvakakosha. Mumutsara uyu, orforglipron inobuda seimwe inovimbisa imwe yakavakirwa pa chikamu 3 uchapupu, ichimirira kubvumidzwa, iyo inogona kufambisa kuwana uye kutevedzera pasina kupa mhedzisiro yekliniki yakakodzera.
